The Cell Biology is so large discipline that is being studied in universities with a separate sub-disciplines. Following this tendency it is convenient to have outlined issues within only the Cell Biology also as the Polyscale subject. A subject with multiple scales itself in spite that cell is so small object. Nevertheless, and biologists know that this tiny Object has tremendous complexity by itself just at the Upper few scales only.
We are repeating here some texts from the General Biology Polyscale description as it is introduced in the above section. We know that, and it is established in the HSP-VAT that the mathematical formulation, statements, and modeling of physical processes occurring in strongly heterogeneous media results on the whole in the necessity for a particular medium scaled characteristics development, and accordingly, for the process each scale governing equations.
This is all applicable to the Heterogeneous Scaled nature of assignments within the Cell Biology as well.
Among major aims of the HSP-VAT application to Cell Biology issues are the following:
1) Provide theoretical derivation of main sets of governing equations (GE) on each level of the hierarchy and estimate feasibility of closure developments.
2) Develop theoretical mechanisms and varieties of closure approaches for each specific biological or/and medicine system hierarchical level.
3) Estimate the feasibility of theoretical procedures for the development of numerical convergent algorithms for solution evaluations of the equations governing the process.
With this below statement we hope to attract attention of people working in Cell Biology and might be thinking that only among them could be found the persons that move forward the discipline's agenda and focus? Well, read this below and be honest to yourself at least.
And remember - Biology can not be sustained by itself without other sciences participation and even guidance.
No matter how hard and how clever people have been trying to do this. Few main reasons for that are given in:
where few words on logic and history of the HSP-VAT are spelled in
along with the fundamental controversial grounds for this currently dominating "theological" physics acting in and on behalf of Biology explained in
See just small portion of arguments in our scaled solutions and data reduction as in
and other subsections of this website. Etc., etc.
Just the short first come first appeared list, following the TOC in many Biology Textbooks:
Proteins:
These sentences above and below on areas of inability to cover them with the homogeneous one-scale physics and chemistry tools, were written as around ~2002-2003, or even earlier. Just recently I was pointed out to the place where people wrote the similar statements on the features of "Protein - to - Protein" or Macromolecule-to-Macromolecule interactions. Where? - in California, and New York; just we can find that in the web -
where they spell the words -"Current technologies are not suitable to reveal dynamic interactions between macromolecules at sufficient scale, with sufficient reliability or with sufficient sensitivity to keep pace with the genomic revolution brought about by sequencing technologies. The vision of the National Center for Dynamic Interactome Research is to develop innovative and dramatically new approaches for the detection, isolation, and analysis of macromolecular complexes that will enable scientists to realize the full potential of the revolution brought about by genomics, interdisciplinary research, and proteomics technologies."
That's good to read. Meanwhile, we have some ideas to tell about on their own tools developed and the results obtained with those tools, a few published in "Nature." The tools are still of the one-scale orthodox homogeneous physics. Scrutiny has been uploaded in the below subsections -
Ferments:
Membranes:
Etc., etc.
Workers went down the scales to the atomic and protein scales. Nevertheless, this won't help in core to find ways to model the polyscale phenomena in 2D or better 3D cross transport polyscale reality. Why is that read in -
Cells: